Solubilization of prostacyclin membrane receptors from human platelets
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چکیده
منابع مشابه
Solubilization of prostacyclin membrane receptors from human platelets.
Prostacyclin (PGI2) receptors have been identified on platelets and other tissues but their physicochemical properties remain unknown due to difficulties in obtaining active solubilized receptors. We evaluated the ability of several detergents to release the receptors from platelet membrane preparations. In contrast to the results of Dutta-Roy and Sinha (Dutta-Roy, A. K., and Sinha, A. K. (1987...
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Prostacyclin (PG12) is the most potent endogenous inhibitor of platelet aggregation. Prostacyclin increases platelet cyclic AMP concentration by activating a receptor on the platelet cell membrane. The characteristics of this receptor have been studied in fractured human platelets from normal subjects by measuring specific binding of tritiated prostacyclin (Blair, Hensby & MacDermot, 1981, Jour...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1989
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)31224-3